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Oxidative stress directly affects mitochondrial function by damaging its membranes and impairing the electron transport chain (ETC) complexes

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Liposomal Glutathione may be a useful nutritionaladjunct for individuals who wish to increase their levelsof the essential antioxidant, glutathione

For macrophage phenotype regulation, Mn 2+ /glycyrrhizic acid self-assembled hydrogels (MnGAHs) remove excess ROS by mimicking Mn-SOD enzymatic activity and downregulate the hypoxia-inducible factor-1 alpha (HIF-1) pathway, promoting the transformation of pro-inflammatory M1 macrophages to repair-type M2 macrophages (increasing the proportion of CD206 + cells to 68%), thereby significantly enhancing IL-10 secretion ( 19