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doi: 10.1006/cyto.1998.0437

In polyhexamethylene guanidine-induced pulmonary fibrosis mice, esculetin (10 mg/kg) antagonizes macrophage infiltration, ameliorates alveolar epithelial barrier disruption and reduces the levels of MMP-9, macrophage inflammatory protein 2, IL-8 and IL-1 (82)

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Mitochondrial respiratory chain complexes I and III can contain electrons derived from NADH and ubiquinone that may interact directly with oxygen-generating ROS [24, 25]

Targeting sterile inflammation Whether sterile inflammation promotes the progression of liver injury or serves as a means of cellular defense against toxicity remains controversial