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Slow movement (bradykinesia) or inability to move (akinesia)Produces difficulties not only with the execution of a movement but also with the planning and initiation of movement

Concomitant intake of this medication with caffeine containing products may cause tension and irritation

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The antennae from three subunits within the trimers wrap around each other and undergo conformational changes as the catalytic cleft opens and closes

The presence of pathological signs at birth and history of epileptic seizures have been strongly associated with poor prognosis (Sofou et al., 2014