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GSH has the function of master antioxidant in all tissues and is involved in antioxidant defense, detoxication of xenobiotics, intracellular redox homeostasis, cysteine carrier/storage, cell signaling, protein folding and function, gene expression, cell differentiation/proliferation, immune response and antiviral defense, that make it a Samsonian (mighty) little molecule (1, 2)

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Gawandi et al

Louis, Missouri, USA: Elsevier Health Sciences (2010)

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression