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Rats had received CYP (HC induction) or saline, then PCE (500 mg/kg orally) or respective vehicle for 14 days

turning around in the standing or recumbent positions, as the disease progresses, the gait patterns becomes slower and the typical parkinsonian gait develops with shuffling and short steps and impaired motor control

doi: 10.7759/CUREUS.1004 62 KlebanoffSJ

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ERAD helps mitigate this burden by degrading these proteins, thereby preventing their aggregation and the subsequent activation of detrimental pathways, such as chronic ER stress, autophagy dysfunction, and apoptotic signaling