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These include: Some serious side effects may occur with Humira that require immediate medical attention, including: hives itching tingling or numbness chest pain pale skin difficulty swallowing difficulty breathing weakness in legs vision problems shortness of breath rash joint pain fever, chills, or other signs of infection swelling in the ankles, feet, legs, or face Humira can also increase the chances of developing skin cancer, lymphoma, and other types of cancer

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(see Table 25) Table 25

Dermatol , 13, 635642 (2004)

The compound's selectivity profile minimizes concerns about off-target effects, but investigators should consider potential interactions with other NAD+-modulating interventions or compounds that affect methylation metabolism