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the tau protein is hyperphosphorylated and amyloid protein is formed, causing nerve fiber damage and nerve fiber degeneration, thus aggravating the neurotoxic iron accumulation

Sequences of proteins and associated tags are listed in Supplementary Table 3

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Ghrelin is a new endogenous peptide, discovered in 1999 by Kojima et al., as the result of a search for an endogenous ligand for an orphan receptor of known structure and function

The side chain oxygen of the glutamate forms a hydrogen bond with the glycine main chains and has a nonbonded contact with the F H16 side chain (Fig