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The buffer solutions were prepared by introducing arginine in the stated molar amount between 5-80 mmol / l and adjusting the pH with phosphoric acid or hydrochloric acid or citric acid

Acknowledgements This work was supported by the BK21 FOUR (Fostering Outstanding Universities for Research) and the Basic Science Research Program through the National Research Foundation of Korea (NRF), by the Ministry of Science and ICT (MSIT) (2022R1A2C1004204), and by the Soonchunhyang University Research Fund

In conclusion, the emphasis should be placed on the research and development of efficacious, multimodal pharmaceuticals that target the intricate complexities of the nervous system

Cook SF, King AD, van den Anker JN et al , Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: method validation and application to a neonatal pharmacokinetic study