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In a phase II trial, adults with a BMI of 30 or 27 kg/m with comorbidities were randomized to receive efpeglenatide at doses of 4 mg weekly, 6 mg weekly, 6 mg biweekly, or 8 mg biweekly, or a placebo, all combined with a hypocaloric diet [17]

It is not possible to culture the T cells persistently in hypoxia for 11 days, as low oxygen levels can stop T cell proliferation