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To elucidate the mechanism underlying metformin-induced increase in GLUT1 expression, we comparatively analyzed the proteins implicated in RNA sequencing data that impact GLUT1 membrane trafficking 24,37,38,39

While externally produced short-lived reactive species such as hydroxyl radicals, superoxide anion radical, and singlet oxygen all decay much too rapidly to enter the human body, photo-oxidation results in a variety of longer lived potentially active compounds, including peroxides, which once ingested or inhaled could conceivably have sufficiently long lifetimes in vivo to cause adverse effects

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Recent findings indicate that M2 phenotypes is further divided into several subtypes, out of which M2d subtype is capable of proinflammatory responses 43