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Another study identified potential inhibitors through in silico screening, discovering several chemotypes that inhibited NAPRT at micromolar concentrations

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Persistent accumulation of activated myofibroblasts within lesional tissue, the hallmark of SSc and other forms of fibrosis, is induced by transforming growth factor- (TGF-), interleukin-6 (IL-6), and a host of other soluble factors 3,8

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