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The main target for Grx2 in mitochondria is Complex I, although UCP3 and the 2-oxoglutarate dehydrogenase (OGDH) have been also shown to be deglutathionylated by Grx2

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Rotenone is known to be a potent inhibitor of complex I of the mitochondrial respiratory chain in all cell types, by inhibiting the function of mitochondrial NADH dehydrogenase activity (Sherer et al ., 2003

In those cases, a single mechanism weight loss drug like semaglutide or liraglutide may be a better option