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PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)

10.1093/advances/nmac032 87

Overcoming these barriers through proper safety testing, innovative large-scale production, and equitable pricing models will be essential to ensure global accessibility