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Qualitative and quantitative changes in the gut microbiota and changes in the amount of neurotransmitters and metabolites of microbial origin have been identified, and support a relevant role of the gut-brain axis in the development of these conditions

Studies have also demonstrated that iron overload and lipid peroxidation are key inducers of ferroptosis in the pathophysiology of SCI (Figure 3B)

An imbalance of T H 1/T H 2-cell responses is thought to contribute to the pathogenesis of various infections, allergic responses and autoimmune diseases