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Approved agents in this space include sermorelin (FDA-approved as a diagnostic agent

Preclinical research has shown that intracavernous delivery of VEGF can restore endothelial function and nerve integrity in diabetic or nerve injury rat models [174]

Idecalcitol, a vitamin D analog, reduces LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts via the Nrf2/HO-1 pathway (83)

Evidence suggests that both endocrine dysfunction and chronic inflammation can also exhibit modulation mediated by epigenetic alterations, indicating this is an area that may offer potential therapeutic targets for the treatment of depression, requiring further studies