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[] Free radicals damage the RBC products by lipid, protein oxidation and oxidative loss with changes in the structure of the RBCs membrane leads to an increase in the accumulation of band-3 protein, lipid oxidation and apoptotic changes in the last weeks of storage

The secondary outcome was the incidence of all-cause mortality

EBioMedicine 2021;71:103560

Role of glutathione S-transferases in protection against lipid peroxidation

However, the development of medications for ASD is complex due to a lack of prior experience in clinical development, a limited understanding of the biology of the disorder, problems in modeling the disease in vitro and in vivo, the variability of symptoms, and the lack of prior involvement in the field [58]