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The synthetic peptide FOX04-DRI selectively disrupts this interaction, thereby restoring the apoptotic activity of p53 and leading to the elimination of senescent cells

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Since H 2 O 2 is involved in the regulation of apoptosis, cell cycle progression and proliferation, the energy metabolism and angiogenesis, specific redox-sensitive targets with redox-sensor functions are necessary (Fig

Given that our list comprised 13 genes, we assigned the first 5 genes to the first tercile, the next 4 to the second tercile, and the final 4 to the third tercile

10.1371/journal.pone.0177121 3