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19 Accumulating preclinical evidence indicates that alterations in the methionine cycle play a pathogenetic role in CLD

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Two of the aforementioned serine residues are located on the more C-terminal loop at the entrance of the substrate channel leading to the respective active site, and phosphorylation of only one of them is sufficient to inactivate pyruvate dehydrogenase, thus demonstrating the out-of-phase coupling between its active sites

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This format supports stability and facilitates controlled dissolution using appropriate sterile solvents