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Current challenges and future implications of exploiting the OMICS data into nutrigenetics and nutrigenomics for personalized diagnosis and nutrition-based care

CY: Data curation, Writing review & editing

I can tell you another thing because this was interesting to me when I first started doing my research in glutathione is because they were injecting this glutathione into the blood and initially they got the results

According to the results of studies revised and discussed in this paper, we identify the following highlights: (i) The low solubility and poor bioavailability of I3C and DIM limit their use as a medical treatment, so it is necessary to increase the research regarding pharmaceutic forms that improve these parameters, (ii) I3C and DIM have pro-apoptotic and antiproliferative effects and inhibit cell growth in pre-clinical and clinical cancer assays (Tables 2 and 3), (iii) Since I3C and DIM derivatives such as 5,5-Br2-DIM, the regulated cellular process associated with hallmarks of cancer, it could be essential to evaluate also these derivatives as anti-cancer agents, maybe in conjunct with DIM or I3C, and finally, (iv) The current evaluation of the anti-tumoral activities of DIM and I3C is generally based on mechanisms involving signalizing ways such as NF- B, Akt, Wnt, PI3K/Akt/mTOR, and AhR

Inhibiting the NF-B signaling pathway and activating the PI3K/AKT signaling pathway are essential for these effects (199201)