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M2-Macrophage-Induced Chronic Inflammation Promotes Reversible Mesenchymal Stromal Cell Senescence and Reduces Their Anti-Fibrotic Properties

Also, a substantial decrease in glutathione levels precedes the mitochondrial dysfunction and neuronal death found in Parkinsons disease, suggesting GSH depletion may initiate the subsequent impairment.It also suggests that increasing GSH levels may have potential benefit toward preventing diseases associated with mitochondrial dysfunction

Acta 1101 , 8489 (1992)

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Quantitative PCR (qPCR) measurements based on isolated mature human fat cells from 22 women and six men (clinical characteristics in Supplementary Table 1), revealed that glutamine synthase ( GLUL ) was lower and GLS was higher comparing cells from participants with versus without obesity (Fig