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In contrast to folate deficiency, the small folate cycle can run almost as normal

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The causative agent, Mycobacterium tuberculosis ( MTB ), infected 10.8 million people and caused 1.25 million deaths in 2023 ( Mycobacterium bovis , is the only licensed vaccine for TB, but has little protective effect against pulmonary disease in adolescents and adults ( The importance of cell-mediated immunity (CMI) in controlling TB, primarily through a T-helper 1 CD4+ T-cell response, has been demonstrated in HIV-infected individuals