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In: Arunachalam B, Yang X, Sasidharan SP (eds) Bioprospecting of tropical medicinal plants

[40] demonstrated in vitro that a decrease in endogenous N/OFQ, or the absence of its receptor, results in an increase in capsaicin-induced bronchoconstriction, indicating the ability of this neuropeptide to modulate bronchoconstriction by affecting sensory fibers

It occurs naturally in human plasma, though levels decline significantly with age

doi: 10.1093/jxb/erp097 3 AlricJ.JohnsonX

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