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Furthermore, irisin supplementation or exercise-induced irisin activation may offer therapeutic potential for metabolic disorders (263)

Annals of Hepatology vol

This was attributed to lower levels of IL-1 in NLRP3 -/- and caspase-1 -/- mice, as the absence of caspase-1 during H7N9 infection resulted in reduced recruitment of pro-inflammatory cells to the lungs