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60 Liraglutide was subsequently approved for marketing in February 2010, 62 and lixisenatide was approved for marketing in the European Union in 2013 for the treatment of T2DM and in the United States in July 2016

This modification is designed to make the glutathione more stable and protect it from being broken down in the gut

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Liver microsomal biotransformation of nitro-aryl drugs: mechanism for potential oxidative stress induction

"They have to be markedly different to their natural form - which is tricky with peptides." Without a patent, he says, companies risk pouring money into a product with little financial protection