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Graphical Abstract Keywords Hyperuricemia, Microbiota, Physical activity, Caveolae, Uric acid metabolism, Cardiovascular diseases, Metabolic syndrome Introduction Hyperuricemia (HU), a metabolic disorder characterized by elevated levels of uric acid (UA) in the bloodstream, is a significant global health concern

As a result, circulating leukocytes are recruited to the site of inflammation, intensifying the inflammatory response

However, there are several in-vivo and in-vitro experiments showing these key events respectively causing each other

the plasma from which was found to contain 0.003% of the administered dose per milliliter [15]

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