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Metformin can activate fork head box O 3 (FOXO3), reducing ROS/RNS level in immune cells ( Anti-inflammatory Mechanisms of Metformin Neuroinflammation widely exists in various central nervous system diseases and is closely related to cognitive dysfunction

To map energy metabolism in the brain at a resolution that would allow pathway-specific insights, we employ neuroimaging transcriptomic techniques in postmortem human brains [36]

doi: 10.1007/s11626-020-00446-5 59 ChenS.WangJ.PengD.LiG.ChenJ.GuX

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This event is responsible for inhibiting the activation of sodium and calcium channels, the activities of which are required for neuronal excitation