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De Vos FY, Bos AM, Schaapveld M, et al

DOI: Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-10-7166-9 Online ISBN: 978-981-10-7167-6 eBook Packages: MedicineMedicine (R0)

Smoking and excessive alcohol intake contribute to stress, reducing enzyme efficiency, whereas moderation preserves balance

As an antioxidant, NAC acts as a reduced thiol donor that supports glutathione resynthesis and may exhibit other antioxidant properties (102, 211)

Activation of Nrf2 by either cellular redox status or pharmacological intervention leads to the up-regulation of over 250 genes encoding proteins that are involved in antioxidant defense systems, redox homeostasis, and xenobiotic detoxification [81]