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475,476 PG acts in concert with NO, and the simultaneous inhibition of nitric oxide synthase-2 (NOS2) and COX2 further hinders this process

That means it has a slowing effect on your brain

At that moment, the thiol of C1226 in the MTase domain flips over to cytosine and initiates a nucleophilic addition reaction to the C-6 atom of cytosine to form a covalent bond (Figure 1C)