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Oxidative stress occurs because of an imbalance between free radicals and antioxidants in your body

2 Duloxetine is the only pharmacologic therapy recommended in the American Society of Clinical Oncology (ASCO) clinical practice guidelines for treatment of CIPN in patients with cancer

Secondly, the amino acid sequence also determines the position of key residues and functional groups on the stapled peptide, influencing bioactivities such as the binding affinity and selectivity towards targeting molecules [26]

Therefore, due to the large volume of SCT-based clinical trials, with almost half (35) of them conducted since 2019, an in-depth exploration of their protocol, results, and effects is needed to provide the reader with an overview of the recent developments within the field

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