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In cholangiocarcinoma, combined BET degradation and mTOR inhibition synergistically reduce acetylation of PSAT1-associated H3K27, inducing PSAT1 downregulation and subsequent dysfunction of the serine-glycine-one-carbon (SGOC) pathway (114)

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Generally, the NSAIDs-induced sphincter failure may be quite prominent, at least in the range of that induced mechanically by prolonged stretch, after tube insertion into the lower esophageal and/or pyloric sphincter and sphincter failure in esophagitis rats (30-32), surgically by anastomosis and fistulas creation (26, 27, 29), or chemically, by huge potassium-overdose application (28)