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2.1.4.1 The engineering continuum: coupling constraint to functional agnosticism Virus-like particle functionalization strategies can be conceptualized along a continuum defined by the degree of thermodynamic coupling between scaffold assembly and antigen incorporation: Genetic fusion (the fully coupled regime): this remains the most structurally deterministic strategy, ensuring strict 1:1 stoichiometry and genetic stability

In order to prevent this phenomenon, catalase (another antioxidant enzyme) which is abundant in the peroxisomes breaks down H2O2 into water and molecular oxygen, consequently curtailing free radical-induced damage (Fig

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Furthermore, this review provides a perspective for future research that may contribute to the development of new drugs for neurodegenerative disease treatments