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[8] It will bind with some medications, making it dangerous to use if medications have recently been used

These challenges include the short half-life and instability of the protein in vivo [106], the requirement of administering high volumes of endostatin to exert their anti-angiogenic effects, which in itself is associated with significant practical and cost implications [107], as well as technological challenges related to manufacturing a correctly folded and soluble protein to ensure adequate bioactivity within the tumour cells [108]

The future agenda entails the standardization of testing protocols, the development of combination therapies, and the advancement of personalized approaches grounded in tissue-specific redox biology

These drugs should be started at low doses, and given adequate time to reach peak effectiveness

TB-500 functions through the control of actin