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Int J Mol Sci 17:1201

We could not obtain an adequate size of HCC and adjacent normal tissues in some patients, so some tissue parameters [i.e., GSSG and ox-LDL] could not be measured, which may have decreased the statistical power to observe the association between the level in plasma and tissues

Richardson DR, Lane DJR, Becker EM, Huang MLH, Whitnall M, Rahmanto YS, et al

Finally, accelerating the entire translational pipeline depends on Advancing Predictive Tools, which entails the development of more physiologically relevant preclinical disease models and the discovery of robust biomarkers to accurately stage disease progression and monitor therapeutic efficacy, thereby de-risking and expediting the journey from bench to bedside

They're FDA-approved