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for example, by adding internal cysteine residues capable of forming intramolecular disulfide bridges which cyclize the peptide

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Encapsulation within advanced nanocarriers (e.g., PLGA nanoparticles, nanostructured lipid carriers, liposomes, mesoporous silica, and biomimetic exosomes) dramatically enhances curcumins aqueous solubility, shields it from rapid degradation and metabolism, and extends systemic circulation

Preclinical and clinical studies have demonstrated the potential of antioxidants, such as N-acetylcysteine, sulforaphane, alpha-lipoic acid, L-carnitine, ascorbic acid, selenocompounds, flavones and zinc, in alleviating neuropsychiatric symptoms by mitigating excitotoxicity, enhancing synaptic plasticity, reducing microglial overactivation and promoting synaptogenesis

PMID 20721027