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Description

It was repeatedly shown that ROS accumulation activates PARP1 as well as augments the overall PARylation level of cellular proteins 118 - 121

It inhibits caspase-3 and enhances B-cell lymphoma 2 (Bcl-2) suggesting its antiapoptotic effect (Janbaz et al

Oncoimmunology 12(1):2174723

Although both pathways demonstrate redundancy at normal pH, our qPCR data, along with previous studies, categorically indicate that the enzyme responsible for carrying out direct sulfhydrylation is over-expressed in M tuberculosis upon exposure to acidic pH 32,34,35