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They act as rate-limiting enzymes in their respective pathways (Grenett et al., 1987)

American Journal of Psychiatry, 158 , 20152021

Moreover, nutrients may indirectly regulate the activity of the vagus nerve by influencing the secretion of gut peptides and neurotransmitters from enteroendocrine cells, like glucose stimulating the release of serotonin, increasing the exposure of receptors to it and thereby activating satiety signaling [40,41]