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supply of a Part B rebatable biosimilar biological product by a manufacturer and significantly affects the ability of the manufacturer of the biosimilar biological product to fill orders or meet expected demand for its product in the United States for at least 90 days

Under homeostatic conditions, NRF2 is sequestered in the cytoplasm through its interaction with the repressor protein KEAP1

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This nerve damage may result from diabetes, vitamin deficiencies, autoimmune disease, chemotherapy, alcohol or drug misuse, and other causes

Pregnant women are advised to ensure adequate folate intake to promote neural tube development, which occurs in the early stages of pregnancy