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N Engl J Med 343:180184 Tepel M, van der Giet M, Statz M, Jankowski J, Zidek W (2003) The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure

This global harmonization promises to improve consistency among global sponsors in applying MIDD in drug development and regulatory interactions, thus bears the potential of promoting more efficient MIDD processes worldwide [6,7,8,9]

This will benefit our understanding of the aetiologies involved in ADs and permit the development of therapeutic strategies that aim to improve intestinal barrier integrity to help tackle the burden caused by inflammatory diseases

Selenium is also included to support key glutathione enzymes

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