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Conversin de Homocistena a metionina , ocurre en el citoplasma celular mediante la enzima metionina sintasa que requiere de la metilcobalamina como cofactor, resultando en una acumulacin de homocistena en plasma si no hay B12

This aligns with the clinical consensus that bypassing the gut and forcing high concentrations of unmethylated B12 into the tissues is a necessary intervention for overcoming post-viral energy crises