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However, whereas the pharmacotherapy literature in cirrhosis has focused primarily on safety, the challenge with non-pharmacologic modalities is the near-absence of efficacy data specific to this population

A., Fontana, L., Lim, A

At the protein level, circadian oscillation of clockwork negative factors such as PERs and CRYs were expected to be in anti-phase with BMAL1, and to be more highly expressed during the dark period relative to the night based on studies on mouse SCN (36)