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Inhibition of PHGDH significantly improved cell viability and reduced cytotoxicity caused by cisplatin in gastric cancer cells, which was partially resulting from decreasing H3K4 tri-methylation and increased chromatin density [99]

This blocking step is followed by a reducing step that converts the GSSG to GSH for quantification in the luminescent reaction

Ser1177 phosphorylation also increases the Ca 2+ sensitivity of the synthase, permitting CaM binding and enzyme activation at lower intracellular Ca 2+ levels (Tran et al., 2009

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Vitiligo can also affect other parts of the body, such as hair and eyes