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Additionally, endoscopic remission (partial Mayo score 1) was seen in 38% of curcumin-treated patients compared to none in the placebo group, with adverse events being rare and similar between the groups

Subsequently, platelet activation via the TLR4-MyD88 pathway promotes thrombotic vessel obstruction (128, 129), signaling that HMGB1 is also a trigger for the formation of NETs (130)

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