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Graphical Abstract 1 Introduction Migraine is a chronic neurovascular disorder, characterized primarily by moderate to severe pulsating headaches accompanied by primary vascular and neurological dysfunction ( Senkyunolides, a class of phthalide-type compounds, are naturally derived from Apiaceae plants such as Ligusticum chuanxiong (Chuanxiong), Angelica sinensis (Danggui), Ligusticum sinense (Gaoben), Apium graveolens (Celery), Opopanax chironium, Lomatium californicum, Cnidium officinale, Cnidii Rhizoma, Levisticum officinale, Angelica acutiloba , and Peucedanum ostruthium ( This review focuses on the anti-migraine pharmacological mechanisms, pharmacokinetic characteristics, and formulation stability optimization strategies of senkyunolides

doi: 10.7861/clinmedicine.15-2-145 Spence, J

In an ongoing phase 1/2 trial (NCT04786262) involving patients with severe T1D, the first treated individual showed detectable endogenous insulin production (measured by C-peptide) and a 91% reduction in exogenous insulin requirement 90 days after infusion of SC-beta cells (stem cellderived, insulin-producing pancreatic cells) [111]

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The Function of astragalus Polysaccharides in Hepatic Steatosis of Mice