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There is a lot of information in the links I've included so I suggest you take a couple of days to look through them

Understanding the Fraught History of the Drug Isotretinoin was originally studied and patented in 1969 by Roche Laboratories as a possible treatment for skin cancer

Oncogene 32 , 40644077 (2013)

PMID: 16152640 Rose PS, Ahn NU, Levy HP, Ahn UM, Davis J, Liberfarb RM, Nallamshetty L, Sponseller PD, Francomano CA

doi:10.1016/j.mad.2005.01.005 436. Jeyaratnaganthan N, Hjlund K, Kroustrup JP, Larsen JF, Bjerre M, Levin K, Beck-Nielsen H, Frago S, Hassan AB, Flyvbjerg A, et al