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However, increased NCOA4-mediated ferritinophagy has been shown to help maintain the growth of pancreatic cancer tumors by promoting mitochondrial ironsulfur cluster protein synthesis and mitochondrial respiration

The mechanisms through which nerve cell apoptosis is inhibited following IS encompass the p38 MAPK/JNK pathways, AIF/Caspase-3, and the Nrf2/HO-1 signaling pathways