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Coronary heart disease (CHD) is a globally prevalent cardiovascular disorder with a complex pathogenesis associated with multiple risk factors, including high-level low-density lipoprotein cholesterol, smoking, chronic kidney disease, diabetes and hypertension (1)

Physiological application of methionine supplementation is dose-dependent, for instance, a low methionine diet suppresses the neurogenesis in animal models, whereas high dietary methionine has been associated with mild cognitive impairment primarily due to mitochondrial dysfunction (197)

EGCG may prolong neuron survival and protect against retrograde apoptosis, potentially preventing neuronal damage [137]

Ind Eng Chem 1924;16(3):307-310

It has been proposed that mitochondrial dysfunction and oxidative stress contribute to the incidence and progression of neurological disorders involving Alzheimers disease