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Comment: One commenter opposed the proposal and recommended that for biosimilars with only negative or zero manufacturer's ASP data, CMS set the payment limit by calculating the volume-weighted ASP using the most recent positive manufacturer's ASP for each NDC in the billing and payment code, while using the current quarter's reported units sold for each NDC

Metabolomic studies have displayed this altered cellular energetics, but the affected metabolites differ between studies (186, 269, 405407)

A study recently put this theory to the test

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