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Bhardwaj H, Jangde RK

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Health Focus: Immune balance, anti-inflammatory effects, support during immune suppression or autoimmune activity

It has been reported that mouse peritoneal resident and Bacillus CalmetteGuerin-activated macrophages and human monocytes are capable of utilising glutamine at high rates, contain sufficient activity of the enzymes required to convert glutamine to citrulline (and subsequently citrulline to arginine via enzymes of a partial urea cycle) to account for observed rates of nitrite synthesis (which in turn is derived from derived from NO) in the absence of extracellular l-arginine, and will release nitrite when exposed to intermediates of the proposed glutamine arginine pathway (Reference Murphy and Newsholme26)