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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

IGF-1 levels in different stages of liver steatosis and its association with metabolic syndrome

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In vitro work using human articular chondrocytes showed dose-dependent increases in type II collagen synthesis and aggrecan (the major cartilage proteoglycan)