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In response to oxidative stress, NRF2 dissociates from KEAP1, translocates to the nucleus, and activates genes encoding antioxidant enzymes (e.g., superoxide dismutase SOD) and glutathione synthesis enzymes, reducing reactive oxygen species (ROS) and mitigating oxidative damage ( Therapeutic interventions targeting redox imbalance in fibromyalgia Currently, there is a lack of randomized controlled trials (RCTs) directly evaluating redox-modulating interventions targeting the central nervous system (CNS) in fibromyalgia

Drug and Alcohol Dependence, 49 , 157163

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J Physiol 2011